In that study, we showed that CBD fully relaxed isolated human pulmonary arteries. However, in contrast to systemic circulation, which is relatively well-examined, there has been only one publication so far concerning the pulmonary arterial bed. Inhalation is the most common route of recreational cannabis consumption in humans. ĬBD causes relaxation of human mesenteric arteries and rat aorta and femoral and mesenteric arteries under normo- and hypertensive conditions. It is approved by the US Food and Drug Administration for the treatment of resistant epilepsy, and it is indicated in the therapy of neuropathic pain in multiple sclerosis and other diseases. It has a broad therapeutic potential resulting from its anti-inflammatory, antioxidant, anticonvulsant, antipsychotic, anxiolytic and antiproliferative properties. Ĭannabidiol (CBD) is a non-psychoactive compound of Cannabis sativa var. Unfortunately, PAH remains an incurable devastating disease that urgently needs new and better therapeutic interventions. PAH is associated with endothelial dysfunction, excessive constriction of pulmonary arteries (PAs), vascular remodeling (smooth muscle cell proliferation and hypertrophy), infiltration of inflammatory cells into the lung and thrombosis. Pulmonary artery hypertension (PAH) is a complex, chronic and multi-factorial disease which can lead, among other complications, to an increase in right ventricle pressure (RVP), resulting in progressive right heart failure and premature death. In conclusion, CBD may be a safe, promising therapeutic or adjuvant therapy agent for the treatment of human pulmonary artery hypertension. Our data suggest that CBD ameliorates MCT-induced PH in rats by improving endothelial efficiency and function, normalization of hemostatic alterations and reduction of enhanced leukocyte count determined in PH. CBD did not affect the cardiopulmonary system of control rats or other parameters of blood morphology in PH. In addition, CBD increased lung levels of some endocannabinoids (anandamide, N-arachidonoyl glycine, linolenoyl ethanolamide, palmitoleoyl ethanolamide and eicosapentaenoyl ethanolamide but not 2-arachidonoylglycerol). CBD improved all abovementioned changes induced by PH except right ventricle hypertrophy and lung edema. PH was connected with elevation of right ventricular systolic pressure right ventricle hypertrophy lung edema pulmonary artery remodeling enhancement of the vasoconstrictor and decreasing vasodilatory responses increases in plasma concentrations of tissue plasminogen activator, plasminogen activator inhibitor type 1 and leukocyte count and a decrease in blood oxygen saturation. The aim of our study was to examine the potential preventive effect of chronic CBD administration (10 mg/kg/day for three weeks) on monocrotaline (MCT)-induced pulmonary hypertension (PH) rats. Cannabidiol (CBD) is known for its vasorelaxant (including in the human pulmonary artery), anti-proliferative and anti-inflammatory properties.
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